Overview Study on Characterisation Chemistry and Pharmacology of Digitalis Glycosides
DOI:
https://doi.org/10.59436/jsiane.302.2583-2093Keywords:
Digitalis purpurea, digoxin, lanatoside C, Plantaginaceae, lucibufagins, ventricular response, DaturaAbstract
Medicinal plants influence human health worldwide and are an integral part of the ecology and environment. Pharmacologically, they have been used to address a number of different ailments in the past. The healing value of plants is attributed to the amount of active chemicals present in their different portions. This review aims to present a current assessment of cardiac glycosides present in African medicinal plants as potentially beneficial treatments. Google, Google Scholar, PubMed, Medline, Research Gate, Web of Sciences, ScienceDirect, and SciFinder were among the online resources used in the literature review. The keywords "natural goods," "pharmacology," "isolated compounds," "cardiac glycosides," "African medicinal plants," and "bioactivity" were employed. Cardiac glycosides have been identified since ancient times and isolated from plants and animals. By strengthening myocardial contractions and reducing their frequency, cardiac glycosides have been employed as drugs to treat heart disorders. As a growing amount of research has. Demonstrated, the biological consequences of these drugs go beyond their capacity to inhibit sodium-potassium pump function. Endogenous and external cardiac glycosides can affect the immune system, bodily defense, carcinogenesis, and hormone regulation, among other processes regulated by these transcription factors, by their interaction with nuclear receptors. Digoxin's proven efficacy, cost, and global accessibility ensure its continued relevance even in the face of newer pharmacological drugs. African medicinal plants have produced several cardiac glycosides with well-established pharmacological characteristics, such as neurotoxic, antiviral, enzyme-inhibitory, cytotoxic, and anti-inflammatory effects. Additionally, they can be thought of as starting combinatorial chemistry structures, which produce fresh molecules with the intended features, including medications. Particularly common cardiac glycosides are found in the Asclepiadaceae and Apocynaceae families.
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