The Advent of Multi-Omics Cancer-Diagnosis: NGS, Bioinformatics and Precision Oncology using Tata Memorial Centre and Homi Bhabha Cancer Model
DOI:
https://doi.org/10.59436/jsiane.v6i2.7.2583-2093Keywords:
Molecular Diagnostics, Next-Generation Sequencing (NGS), Precision Oncology, Bioinformatics, Statistics, Advanced Cancer Research, Tata Memorial center (TMC), Homi Bhabha Cancer Hospital (HBCH&RC)Abstract
Recent years have led to the exploration of cancer diagnostic techniques. No longer are we stuck on the one-size-fits-all approach, but a method of diagnosing cancer specific to each individual, using a combination of numerous oncological tests at once. This review explains why the Homi Bhabha Cancer Hospital and Research Center in New Chandigarh has established a centralized system via the hub and spoke model, allowing different communities in India to have decentralized access. Multi-Omics Oncology diagnostics have brought our labs from generalized cytotoxic treatment to specific analysis of molecular aberrations using techniques such as polymerase chain reaction (PCR), next-generation sequencing (NGS), and fluorescence in situ hybridization (FISH). We will also learn about the additional step of our multi-factor detection becoming intelligent clinical diagnostics with the help of GATK and statistical modeling (Kaplan-Meier survival analysis)
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