Analysis of the protective effects of extracts from the therapeutic plant Aegle marmelos against cisplatin-induced toxicity
DOI:
https://doi.org/10.59436/jsiane.293.2583-2093Keywords:
Medicinal plant extracts, protective effects, cisplatin-induced toxicity, antioxidant activity., Aegle marmelosAbstract
An important field of research in the fight against chemotherapy's negative side effects is the assessment of medicinal plant extracts for their protective benefits against cisplatin-induced toxicity. Many different types of cancer are treated with cisplatin, a chemotherapeutic drug based on platinum. The significant adverse effects of cisplatin, including nephrotoxicity, hepatotoxicity, and ototoxicity, frequently restrict its clinical utility, despite its efficiency. Damage to non-target tissues, including oxidative stress, inflammation, and apoptosis, causes these harmful effects. So, finding preventive medicines that can reduce these side effects of cisplatin without reducing its anticancer effectiveness is an urgent requirement. There is a wealth of bioactive substances found in medicinal plants that may have medicinal uses; these plants have a long history of use in traditional medical systems around the world. The established antioxidant, anti-inflammatory, and cytoprotective activities of these plants form the basis for their research as protective agents against cisplatin toxicity. The primary goals of this research are to determine which medicinal plant extracts are most effective at reducing cisplatin-induced toxicity and, secondarily, to determine the mechanisms of action and possible therapeutic uses of these extracts.
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