PROTECTIVE EFFECT OF TRIBULUS TERRESTRIS ON HEPATO-BIOCHEMICAL PARAMETERS OF ALBINO RAT AFTER TREATMENT WITH DRUG CYPROTERONE ACETATE

Abstract

The study investigates the hepatoprotective effects of Tribulus terrestris on albino rats subjected to cyproterone acetate, drug known for their hepatotoxicity. The experiment involved the administration of this drug to induce liver damage, followed by treatment with Tribulus terrestris extract. Hepato-biochemical parameters, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were monitored to assess liver function and damage. Results showed a significant elevation in ALT, AST and ALP levels in rats treated with cyproterone acetate, indicating liver damage. However, co-administration of Tribulus terrestris extract resulted in a marked reduction in these biochemical parameters, suggesting a protective effect on liver function. The study concludes that Tribulus terrestris exhibits substantial hepatoprotective and antioxidant effects, potentially mitigating the hepatotoxicity induced by cyproterone acetate. These findings suggest that Tribulus terrestris could be considered as a supplementary therapeutic agent to protect against drug-induced liver damage.