EFFECT OF ALUMINIUM FLUORIDE ON LIVER FUNCTIONS OF RATTUSNORVEGICUS AFTER AMELIORATION BY MORINGA OLEIFERA
DOI:
https://doi.org/10.59436/jsiane.com/archives3/3/92Keywords:
Aluminium, Fluoride, Moringa oleifera, Albino Rat, SGPT, SGOT, ALP.Abstract
Animals and humans are frequently exposed to aluminium and fluoride, and poisoning can occur. Ingestion of aluminiumfluoride occurs primarily through inhalation of aerosols or particles, food, water and medication. This study addresses the serious effects of aluminum fluoride on liver function in albino rats (SGPT, SGOT and ALP) and their amelioration by Moringa oleifera. In this study, we selected 150 healthy adult male albino rats of almost same size and weight ((120 ± 25 gm) and eight weeks old)(because they have the same physiology as humans) and divided them into three groups (control group, treated-I with ALF and treated-II (ALF + Moringa). Rats were maintained on the diet selected according to diagnosis. According to the experimental protocol, rats were exposed to aluminum fluoride and Moringa. Biochemical studies of blood were performed according to standard methods and procedures. Significant changes in liver function (SGOT, SGPT and ALP) were observed in this study. The results showed that excessive aluminum fluoride intake worsened liver function, possibly due to the toxicity of aluminum fluoride. Aluminum fluoride induced liver dysfunction is mediated by increased oxidative stress in rats. Aluminum fluoride has a negative effect on blood sugar in albino rats. However, by including moringa in the treatment of albino rat, the negative effects of fluoride are reduced due to its healing effects.
References
Abbas ali, K.M., Zhila T. and Farshad, N. (2005), Developmental toxicity of aluminium from high doses of AlCl3 in mice. The J. of App. Res., 5:575-579.
Blaszczyk, I., Gruncka, M., Kasperczyk, S. and Birkner, E. (2008). Influence of fluoride on rat kidney antioxidant system: Effects of Methionine and Vitamin E. Biol. Trace Ele. Res., 121(1): 51-59.
Carlson, C.H., Armstrong, W.D. and Singer, L. (1960 a). Distribution and excretion of radio fluoride in the human. Proc. Soc. Exp. Biol. Med., 104: 235-239.
Chinoy, N.J., Sharma, M. and Michael, M. (1993). Beneficial effects of ascorbic acid and Calcium on reversal of fluoride toxicity in male rats, Fluoride, 26(1): 45-56.
Fakurazi, S., Sharifudin, S.A. and Arulselvan, P.M. (2012). Oleifera hydroethanolic extracts effectively alleviate acetaminophen-induces hepatotoxicity in experimental rats through their antioxidant nature. Molecules 17:8334–8350,
Fischer and Yates (1950). Statistical tables for biological, agriculture and medical research, Longman, VIth edition. pp x+146.
Kaur, K., Koul, M.L. and Koul, R.I. (1981). Histological changes in liver following Sodium fluoride ingestion, fluoride; 14: 119-123.
Ludlow, M., Luxton, G. and Mathew, T. (2007). Effects of fluoridation of community water supplies for people with chronic kidney disease. Nephrol Dial Transplant, 22: 2763–2767.
Newairy, A.S., Salama, A.F., Hussein, H.M. and Yousef, M.I. (2009) Propolin alleviates aluminium induced lipid peroxidation and biochemical parameters in male rats. Food and Chemical Toxicology, 47(6): 1093-1098.
Panda, L., Kar, B.B. and Patra, B.B. (2015). Fluoride and its health impacts-a critical review. IOSR J Elect Communication Engg., 10: 79–91.
Sahay, M. (1986). Histopathological and cytogenetic effect of alfatoxins in Mammal, Ph.D Thesis: T.M Bhagalpur Univ. Bhagalpur.
Saalu, L.C., Ogunlade, B., Ajayi, G.O., Oyewopo, A.O., Akunna, G.G. and Ogunmodede, O.S. (2012). The hepatoprotective potentials of Moringa oleifera leaf extract on alcohol induced hepato-toxicity in Wistar rat. American J. of Biotech. and Mol. Sc., 2(1): 6-14.
Verma, R.J. and Sherlin, D.M. (2001). Moringa oleifera ameliorates fluoride induced embryotoxicity in pregnant rats. Hum. Exp. Toxicol., 20(2): 619-23.
Yang, K. and Liang, X. (2011). Fluoride in drinking water: effect on liver and kidney function. In: Nriagu, JO (ed.), Encyclopedia of Environmental Health. Burlington: Elsevier, 769–775.
Zhan, X., Xu, Z., Li, J. and Wang, M. (2005). Effects of fluorosis on lipid peroxidation and antioxidant systems in young pigs, fluoride; 38: 157-161.
Zhang, K. and Zhou, Q. (2005) Toxic effects of aluminium based coagulants on Brassica chimensis and Raphanus sativus growing in acid and neutral conditions. Environ. Tox., 20(2): 179-187.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
