Impact of Smokeless Tobacco Product Consumption on Certain Haematological Parameters in Albino Rats
DOI:
https://doi.org/10.59436/jsiane.335.2583-2093Keywords:
Smokeless tobacco Snuff and Haematological parameters.Abstract
The tobacco plant (Nicotiana tabacum) has historically been utilized as chewing tobacco globally. Snuff is a form of tobacco processed into small particles and packaged in cans or pouches. This study aimed to investigate the impact of snuff tobacco on certain hematological indicators in albino rats. Albino rats with a weight range of 100 to 150 grams were utilized in the study. The oral LD50 for tobacco snuff was established at 3 mg per 100 g of rat body mass. Group A served as the control and received no treatment, whereas group B was administered snuff in milligrams per body weight orally using a gavage tube daily for 28 days. Blood samples were collected under chloroform anesthesia and analyzed for total erythrocyte count, total leucocyte count, hemoglobin concentration, packed cell volume, erythrocyte sedimentation rate, and absolute values. Total Erythrocyte count (TEC) was significantly decreased in group B (5.41±0.04 million/mm3) as compared to the control (6.33±0.3 million/mm3). Total Leucocyte Count was significantly increased in group B (9.0±0.21 x109/L) respectively as compared to the control group A (7.2±0.28 x109/L). Haemoglobin concentration was significantly decreased. Smokeless tobacco may possibly affect all the Haematological parameters.
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