AMELIORATIVE EFFECT OF TRIBULUS TERRESTRIS ON LIVER BIOCHEMICAL PARAMETERS IN ALBINO RAT AFTER TREATMENT WITH DRUG FLUTAMIDE
Keywords:
Flutamide, Tribulus terrestris, ALT, AST, ALP, Albino Rat, hepatotoxicAbstract
Chemicals that lessen the harmful effects of hepatotoxic substances on the liver are known as hepatoprotective agents.While some researchers thought of strengthening, tonic, and fortifying. Tribulus terrestris, a leafy herb used in folk medicine, has shown hepatoprotective effects in several studies. The experiment involved the administration of drug toinduce liver damage, followed by treatment with Tribulus terrestris extract. Hepato-biochemical parameters, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were monitored to assess liver function and damage. Results showed a significant elevation in ALT, AST and ALP levels in rats treated with flutamide. However, co-administration of Tribulus terrestris extract resulted in a marked reduction in these biochemical parameters, suggesting a protective effect on liver function. The study clearly states that Tribulus terrestris extract exhibits hepatoprotective and effect, mitigating the hepatotoxicity induced by flutamide. These findings suggest that Tribulus terrestris could be considered as a supplementary agent to protect against drug-induced liver damage during long term treatments.
References
Chhatre, S., Nesari, T., Somani, G., Kanchan, D., & Sathaye, S. (2014). Phytopharmacological overview of Tribulus terrestris. Pharmacognosy Reviews, 8(15), 45–51.
Fischer and Yates. Statistical tables for biological, agriculture and medical research, Longman, VIth edition. 1950 pp 146.
Goyal, P. K., Verma, P., Sharma, P., Parmar, J., & Aggarwal, M. (2014). Hepatoprotective effects of Tribulus terrestris against lithium-induced oxidative damage in rats. Pharmacognosy Magazine, 10(40), 415–421.
Kazemi, M., Khadem Haghighian, H., & Golestani, A. (2018). Protective effects of Tribulus terrestris L. aerial parts ethanolic extract on liver injury induced by methotrexate in rats. Journal of HerbMed Pharmacology, 7(3), 184–189.
Kind PR, King E. Estimation of plasma phosphatase by determination of hydrolysed phenol with aminoantipyri e. Journal of clinical Pathology. 1954 Nov;7(4):322.
Oner, J., Ozan, T., Akar, A., Demir, T., & Oner, H. (2012). The protective effects of vitamin E and selenium on the liver in rats receiving flutamide: a controlled experimental study. Andrologia, 44(S1), 451–455.
Reitman S and Frankel S. Estimation of SGOT and SGPT in serum. Am J Chem Path 1957; 28: 56-62.
Saberi-Karimian, M., Katsiki, N., Caraglia, M., Boccellino, M., Majeed, M., & Sahebkar, A. (2019). Molecular
mechanisms by which Flutamide inhibits human hepatocellular carcinoma growth. Anticancer Research,
(3), 1153–1159.
Sharma, R., Gupta, R., & Katiyar, C. K. (2021). Protective role of Tribulus terrestris against alcohol-induced
hepatotoxicity in albino rats. Indian Journal of Pharmacology, 53(3), 236–241.
Strumberg, D., Brugger, W., Korn, M. W., Koeppen, S., Ranft, J., Scheiber, G., & Reiners, C. (2002). Evaluation of long-term toxicity in patients after cisplatin-based chemotherapy for non-seminomatous testicular cancer. Annals of Oncology, 13(2), 229–236.
Tajmohammadi, A., Razavi, B. M., Hosseinzadeh, H., & Movassaghi, A. R. (2019). Hepatoprotective effect of Tribulus terrestris ethanolic extract against acetaminophen-induced toxicity in a mouse model. Pharmaceutical Biology, 57(1), 263–269.
Žaja, O., Marjanović, A. M., & Romić, Ž. (2015). Flutamideinduced hepatic dysfunction in rats: the involvement of oxidative stress and nitric oxide. Journal of Applied Toxicology, 35(12), 1593–1602.
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