EFFECT OF NICKEL NITRATE ON RENAL FUNCTIONS OF ALBINO RAT

Abstract

The purpose of this research was to investigate the absorption of nickel nitrate in rats using a renal approach at nickel concentrations of 400, 800, 1600, 3200, and 6400 mg/kg body weight using the renal technique. When nickel concentrations are less than 100 mg/kg body weight, active transport and facilitated diffusion play a critical role in the renal absorption of nickel. Because of saturation of the carriers at greater concentrations, the absorption rate would be reduced at higher concentrations. The distribution of nickel absorbed was investigated by the use of a 100 mg Ni/kg body weight solution administered over a period of 1 to 14 days. The liver is the organ that absorbs the most nickel nitrate, both in terms of concentration and quantity, followed by the kidney. It was discovered that 10% of the original concentration had crossed through the intestinal barrier after 14 days of collection when all of the collected organs (renal function) and blood were tested, but not the liver, after 14 days of collection..