A REVIEW ON THE RECEPTORS AND PATHWAYS USED BY THE DENGUE VIRUS TO INFECT HOST CELLS

Abstract

Dengue fever is caused by a virus that belongs to the Flaviviridae family. Around 400 million individuals worldwide contract the mosquito-borne disease dengue each year, which has a 20% fatality rate in patients who have the most severe cases. People may contract many acute DENV infections during their lifetimes because there are four DENV serotypes, each of which has some immunologic cross-reactivity. A vaccine that is active against all four DENV serotypes has not yet been created. Studies on the virus's receptors and transmission pathways identified putative host targets crucial for virus internalization and propagation in host cells. In this review article, we'll cover information about potential receptors and attachment sites in mammalian and mosquito cells. We'll also go through the many entry points and mechanisms that enable the viral genome to reach the cytoplasm and lead to the internalization of the virus.