EFFECT OF CARBON TETRACHLORIDE ON BIOCHEMICAL PARAMETERS IN BLOOD OF ALBINO RAT AFTER DRUG SUPPLEMENTATION

Abstract

CCl4 is considered very toxic. Suspected carcinogenic to humans based on adequate evidence of carcinogenicity from animal studies. How does carbon tetrachloride affect children's health? The effects of carbon tetrachloride on child health have not been adequately studied. Carbon tetrachloride is an organic compound that can damage the liver by causing a state of oxidative stress. Carbon tetrachloride (CCl4) binds triacylglycerols and phospholipids throughout the subcellular fraction and causes lipid peroxidation in hepatocytes. CCl4 is a highly hepatotoxic xenobiotic and exposure to CCl4 directly causes hepatic necrosis and steatosis (Gu X and Manautou JE, Hodgman MJ, Garrard AR 2012). Mechanistic studies provide evidence that the metabolism of CCl4 to strongly reactive free radical metabolites by CYP2E1 plays an important role in the strategy mode of action. Metadoxin drug is known for its hepatoprotective potential and used in this study. Compataive effect of the plant extract of Phyllanthus niruri and Urtica dioica has been observed with the drug in albino rats for hepatoprotectant action.