QUALITATIVE ANALYSIS OF PHYTOCHEMICALS IN THREE ANTI-DIABETIC MEDICINAL PLANTS OF BRAJ REGION OF UTTAR PRADESH
DOI:
https://doi.org/10.59436/5q1nhv85Keywords:
Diabetes, phytochemicals, anti - diabetic plant, qualitative analysis, different extractsAbstract
Diabetes mellitus is a group of chronic metabolic disorder characterized by hyperglycemia or increased blood glucose levels and eventually leads to damage of multiple body systems due to interference in carbohydrate, fat and protein metabolism following from comparable insufficiency of insulin oozing. Bioactive constituents revealed the presence of flavonoids, alkaloids, phenolic compounds, glycosides, sterols and terpenoids for treatment of diabetic activity in selected medicinal plants of Braj region of Uttar Pradesh such as Aloe vera, China rose and Jamun which possess ability to reduce blood glucose, urea, uric acid and creatinine and to increase insulin level, C-peptide and albumin control level. According to International Diabetes Federation (IDF), it is predicted that the number of diabetic patients in the World could reach up to 366 million by the year 2030. Aim of the present study showed the effect of different extracts such as aqueous, methanolic, ethanolic, acetone, chloroform and petroleum ether with various combinations to evaluate the presence of phytochemicals. Strongly presence of flavonoids with aqueous and methanolic leaves extracts according to other solvents in Aloe vera. In an aqueous leaves extracts of China rose, strongly presence of flavonoids and terpenoids according to other phytochemicals and alkaloids, flavonoids, phenolic compounds, terpenoids and glycosides in methanolic and ethanolic leaves extracts. Strongly presence of alkaloids, flavonoids, phenolic compounds, terpenoids and glycosides in an aqueous and methanolic leaves extracts of Jamun but the absence of tannin in all solvents. So, the aqueous, methanolic and ethanolic extracts are better for Aloe vera, China rose and Jamun for extraction of pytochemicals like alkaloids and flavonoids will be an effective tool for the treatment of diabetes and needs more study for drug development.
References
Agarwal, P., Gaur, P.K., Tyagi, N., Puri, D., Kumar, N. and Kumar, S.S. (2019). An overview of phytochemical, therapeutic, pharmacological and traditional importance of Syzygium cumini. Asian Journal of Pharmacognosy. 3(1):5-17.
Agrahari, D. and Dwivedi, A.K. (2022). Prediction and diagnosis of Diabetes mellitus using data mining algorithms. Dogo Rangsang Research Journal. 12(9):67-79.
Al-Snafi, A.E., Majid, W.J. and Talab, T.A, (2019). Medicinal plants with anti-diabetic effects-An overview (Part 1). IOSR Journal of Pharmacy. 9(3): 9-46.
Ali, H. (2003). An investigation of antimicrobial compounds for immuno-modulating and anti-adhesion properties. Immunology and Infectious Disease and Research Laboratory. 1-186.
Bala, R., Kaur, R., Kaur, B. and Kaur, P. (2022). Hibiscus rosa-sinensis Linn.: A phytochemical and pharmacological review. International Journal of Health Sciences. 6(S3):5165-5193. DOI: https://doi.org/10.53730/ijhs.v6nS3.7050
Baliga, M.S., Fernandes, S., Thilakchand, K.R., D’Souza, P. and Rao, S. (2013). Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (black plum), traditional medicinal plant of India. Journal of Alternative and Complementary Medicine. 19(3):191-197. DOI: https://doi.org/10.1089/acm.2011.0752
Bozzi, A., Perrin, C., Austin, S. and Vera, F.A. (2007). Quality and authenticity of commercial Aloe vera gel powders. Journal of Food Chemistry. 103(1):22-30. DOI: https://doi.org/10.1016/j.foodchem.2006.05.061
Brain, K.R. and Turner, T.D. (1975). The practical evaluation of phytopharmaceuticals, right-science technical, (1st edition). Bristol Britain.144.
Eddouks, M., Bidi, A., El-Bouhali, B., Hajji, L. and Zeggwagh, N.A. (2014). Antidiabetic plants improving insulin sensitivity. Journal of Pharmacy and Pharmacology. 66(9):1197-1214. DOI: https://doi.org/10.1111/jphp.12243
Franco, R.R., Zabisky, L.F.R., Junior, J.P.L., Alves, V.H.M., Jusino, A.B., Saraiva, A.L., Goulart, L.R. and Espindola, F.S. (2020). Anti-diabetic effects of Syzygium cumini leaves: a non-hemolytic plant with potential against process of oxidation, glycation, inflammation and digestive enzymes catalysis. Journal of Ethnopharmacology. 261:113-132. DOI: https://doi.org/10.1016/j.jep.2020.113132
Hasler, C.M. and Blumberg, J.B. (1999). Phytochemicals: biochemistry and physiology introduction. The Journal of Nutrition. 129(3):756-757. DOI: https://doi.org/10.1093/jn/129.3.756S
Jadhav, V.M., Thorat, R.M., Kadam, V.J. and Sathe, N.S. (2009). Hibiscus rosa sinensis Linn-‘‘Rudrapuspa’’: a review. Journal of Pharmacy Research. 2(7):1168-1173.
Jafri, S.A., Hasan, S.S., Nadeem, A., Kalsoom, and Iqbal, J. (2011). Hypoglycemic effect of Aloe vera extract in alloxan-induced diabetic albino rats. Medicinal Journal of Islamic World Academic Sciences. 19(3):127-130.
Khin, P.P., Lee, J.H. and Jun, H.S. (2023). Pancreatic beta-cell dysfunction in type 2 diabetes. European Journal of Inflammation. 21. DOI: https://doi.org/10.1177/1721727X231154152
Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A. and Prakash, O. (2020). A review on Diabetes mellitus: Type 1 & Type 2. World Journal of Pharmacy and Pharmaceutical Sciences. 9(10):838-850.
Kumawat, M., Damor, J., Kachchhwaha, J., Garg, A.K. and Singh, C. (2018). Pharmacological properties and therapeutic potential of Syzygium cumini (Jamun): A review. World Journal of Pharmaceutical Sciences. 7(3):312-322.
Labban, L. and Malek, Z. (2019). The effects of hypoglycemic and hypolipidemic properties of Aloe vera on Type 2 Diabetics. Annals of Food and Nutrition Research Journal. 1(1):1-6.
Margaret, E., Shailaja, A.M. and Rao, V.V. (2015). Evaluation of antioxidant activity in different parts of Syzygium cumini L. International Journal of Current Microbiology and Applied Sciences. 4(9):372-379.
Moqbel, F.S., Naik, P.R., Najma, H.M. and Selvaraj, S. (2011). Anti-diabetic properties of Hibiscus rosa-sinensis L. leaf extract fractions on non - obese diabetic (NOD) mouse. International Journal of Experimental Biology. 49:24-29.
Okeke, M.L., Iroegbu, C.U., Ere, E.N., Okoli, A.S. and Eximone, C.O. (2001). Evaluation of extracts of the root of Landolphia owerrience for antibacterial activity. Journal of Ethnopharmacology. 78(2&3):119-127. DOI: https://doi.org/10.1016/S0378-8741(01)00307-5
Paul, S.U., Dutta, S.O., Chaudhuri, T.K. and Bhattacharjee, S.O. (2014). Anti-inflammatory and protective properties of Aloe vera leaf crude gel in carrageen an induced acute inflammatory rat models. International Journal of Pharmacy and Pharmaceutical Sciences. 6(9):368-371.
Pethe, M., Yelwatkar, S., Gujar, V., Varma, S. and Manchalwar, S. (2017). Anti-diabetic, hypolipidimic and anti-oxidant activities of Hibiscus rosa-sinensis flower extract in Alloxan induced diabetes in rabbits. International Journal of Biomedical and Advance Research. 8(4):138-143.
Pillai, S.S. and Mini, S. (2016). Hibiscus rosa-sinensis Linn. petals modulated glycogen metabolism and glucose homeostasis signalling pathway in streptozotocin-induced experimental diabetes. Plant Foods for Human Nutrition. 71:42-48. DOI: https://doi.org/10.1007/s11130-015-0521-6
Pozzilli, P. and Guglielmi, C. (2009). Double diabetes: a mixture of type 1 and type 2 diabetes in youth. Endocrine Development. 14:151-166. DOI: https://doi.org/10.1159/000207484
Pozzilli, P., Chiara, G., Caprio, S. and Buzzetti, R. (2011). Obesity, autoimmunity and double diabetes in youth. Diabetes Care. 34(2):166-170. DOI: https://doi.org/10.2337/dc11-s213
Rashid, F., Javaid, A., Ashfaq, U.A., Sufyan, M., Alshammari, A., Alharbi, M. and Khurshid, M. (2022). Integrating pharmacological and computational approaches for the phytochemical analysis of Syzygium cumini and its anti-diabetic potential. Molecules. 27(17):5734. DOI: https://doi.org/10.3390/molecules27175734
Salehi, B., Ata, A., Kumar, V.A.N., Sharopov, F., Ramírez-Alarcón, K., Ruiz-Ortega, A. and Sharifi-Rad, J. (2019). Antidiabetic potential of medicinal plants and their active components. Biomolecules. 9(10):551. DOI: https://doi.org/10.3390/biom9100551
Saleem, M., Sharif, M.K. and Saleem, R. (2021). Antidiabetic potential of Aloe barbadensis Miller. RADS Journal of Biological Research and Applied Sciences. 12(1):81-89. DOI: https://doi.org/10.37962/jbas.v12i1.294
Saxena, M., Saxena, J., Nema, R., Singh, D. and Gupta, A. (2013). Phytochemistry of medicinal plants. Journal of Pharmacognosy and Phytochemistry. 1(6):168-182.
Sawant, L., Singh, V.K., Dethe, S., Bhaskar, A., Balchandran, J., Mundkinajeddu, D. and Agarwal, A. (2015). Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds from Syzygium cumini seeds. Pharmaceutical Biology. 53(8):1176-1182. DOI: https://doi.org/10.3109/13880209.2014.967784
Sharma, P., Kharkwal, A.C., Kharkwal, H., Abdin, M.Z. and Varma, A. (2014). A review on pharmacological properties of Aloe vera. International Journal of Pharmaceutical Sciences Review and Research. 29(2):31-37.
Shandilya, S. and Pathak, V. (2020).Chemical constituents and pharmacological effects of Hibiscus rosa-sinensis (China rose)-a review. World Journal of Pharmaceutical Research. 10(1):858-869.
Shivashankar, M. and Mani, D. (2011). A brief overview of diabetes. International Journal of Pharmacy and Pharmaceutical Sciences. 3(4):22-27.
Swami, B.S., Singh, N., Meghatai, M.P. and Parag, M.H. (2012). Jamun (Syzygium cumini (L.): A review of its food and medicinal uses. Food and Nutrition Sciences. 3(8):18.
Tiwari, M. and Upadhayay, M. (2018). The medicinal plant components and applications (Aloe vera). Journal of Medicinal Plants Studies. 6(3):89-95.
Whiting, D.R., Guariguata, L., Weil, C. and Shaw, J. (2011). IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical Practice. 94(3):311-321. DOI: https://doi.org/10.1016/j.diabres.2011.10.029
Zakaria, M. and Mohd, A.M. (2010). Traditional Malay medicinal plants. Institute Terjemahan Negara Malysia Berhad.185.
Zhang, C.L. and Ning, Y. (2011). Effect of dietary and lifestyle factors on the risk of gestational diabetes: review of epidemiologic evidence. American Journal of Clinical Nutrition. 94(6):1975-1979. DOI: https://doi.org/10.3945/ajcn.110.001032
Zore, G.B., Surwase, B.S. and Karuppayil, S.M. (2004). Antifungal activity of two medicinal plants. Journal of Mycology and Plant Pathology. 34(2):543-545.
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