Systematic review on food additives and impact on human health
DOI:
https://doi.org/10.59436/jsiane.397.2583-2093Keywords:
Food, Food Additives, Health RisksAbstract
A lot of people have been exposed to food additive compounds used to keep flavor, improve taste, and make food look better because processed food consumption has been on the rise around the world. While these medications are typically deemed safe when used within recommended dosages, new studies have brought up concerns over their potential impact on human health in the long run. Artificial sweeteners, colorants, emulsifiers, and flavor enhancers are some of the common additives whose effects are discussed in this article. Sodium nitrite, titanium dioxide, and monosodium glutamate (MSG) are among the chemicals linked to an increased risk of metabolic syndrome, allergic reactions, behavioral abnormalities, and changes in gut flora, according to the research. Many people are worried about the long-term effects of these newest additions, especially those who are already at a higher risk, such as youngsters and those with health issues. New regulatory criteria are needed, and there are gaps in additive safety testing and limitations in current toxicological studies. Greater public knowledge, clearer food labels, and longer, more rigorous human research are all essential to reduce hazards and safeguard consumer health.
References
Afsharian, M., Ahn, H., & Thanassoulis, E. (2024). Incentivizing centrally regulated units to improve performance: Pitfalls and requirements. Journal of the Operational Research Society, 75(2), 395-409.
Alieva, M., & Muratova, A. (2024). The Depiction of Childhood in English Fairy Tales and Folklore. Бюллетень науки и практики, 10(10), 419-428.
Aristizabal, M. A., Bruce, C. J., Caruso, M. A., Wieczorek, M. A., Pacheco-Spann, L. M., Carter, R. E., Bruce, A. J., & Hall, M. R. (2025). Allergic contact dermatitis revisited: A comprehensive review. JAAD Reviews.
Boateng, I. D. (2022). A critical review of ginkgolic acids in Ginkgo biloba leaf extract (EGb): toxicity and technologies to remove ginkgolic acids and their promising bioactivities. Food & Function, 13(18), 9226-9242.
Çubuk, S., Kaplan, P., Nallbani, B. G., Yetimoğlu, E. K., & Kahraman, M. V. (2025). A versatile reusable polymer-based sensor for aluminum analysis in various food matrices. Food Chemistry, 471, 142809.
Food, U., & Administration, D. (1993). Everything added to food in the United States. Smoley. García‐Ortega, P., Scorza, E., & Teniente, A. (2010). Basophil activation test in the diagnosis of sulphite‐induced immediate urticaria. Clinical & Experimental Allergy, 40(4), 688-690.
Gatasheh, M. K. (2025). Isolation, Characterization and Probiotic Properties of Levilactobacillus brevis FS1 from Fermented Food and Its Impact on Differentiation and Fat Deposition. Indian Journal of Microbiology, 1-10.
Gupta, M. K., & Basavaraj, G. (2021). Sulphites in food & drinks in asthmatic adults & children: What we need to know. Indian Journal of Allergy, Asthma and Immunology, 35(2), 43-47.
Heshmat-Ghahdarijani, K., Vaseghi, G., Hajian, S., Taheri, M., Haghjooy-Javanmard, S., Sarrafzadegan, N., Habibi, D., Babak, A., & Rad, M. R. (2024). Alterations in serum levels of calcium, vitamin D, phosphorus, and parathyroid hormone in patients with clinically confirmed familial hypercholesterolemia: a cross-sectional study. Annals of Medicine and Surgery, 86(11), 6502-6506.
Levine, A. R., Picoraro, J. A., Dorfzaun, S., & LeLeiko, N. S. (2022). Emulsifiers and intestinal health: an introduction. Journal of pediatric gastroenterology and nutrition, 74(3), 314-319.
Miller, M., & Millstone, E. (1987). Food Additives Campaign Team: Report on Colour Additives. FACT, London.
Montera, V. d. S. P., Martins, A. P. B., Mais, L. A., & Canella, D. S. (2023). Informação sobre aditivos alimentares nos rótulos de alimentos no Brasil: análise crítica. Revista de Saúde Pública, 57, 2.
Neto, A. d. A. P., da Câmara, C. A. G., Monteiro, V. B., Moraes, M. M., Melo, J. P. R., & Leal, T. T. B. (2024). Bioactivity of essential oils from three species of Mentha against Plutella xylostella (Lepidoptera: Plutellidae).
Obeid, E., Le Folcalvez, X., Ezzedine, K., Palomar-Cros, A., Péneau, S., Bellicha, A., Deschasaux-Tanguy, M., Touvier, M., Andreeva, V., & Srour, B. (2024). Meal timing and risk of metabolic syndrome in the prospective French NutriNet-Santé biobank. European Journal of Public Health, 34(Supplement_3), ckae144. 709.
Rachael Zimlich RN, B. (2020). Food additives can be endocrine disruptors. Contemporary Pediatrics, 37(3), 21-22.
Schoenthaler, S. J., Doraz, W. E., & Wakefield, J. A. (1986). The impact of a low food additive and sucrose diet on academic performance in 803 New York City public schools. International Journal of Biosocial Research.
Shepitko, V. Y., & Shepitko, M. V. (2021). The role of forensic science and forensic examination in international cooperation in the investigation of crimes. Journal of the National Academy of Legal Sciences of Ukraine, 28(1), 179-186.
Vally, H., & Misso, N. L. (2012). Adverse reactions to the sulphite additives. Gastroenterology and hepatology from bed to bench, 5(1), 16.
Whelan, K., Bancil, A. S., Lindsay, J. O., & Chassaing, B. (2024). Ultra-processed foods and food additives in gut health and disease. Nature Reviews Gastroenterology & Hepatology, 21(6), 406-427.
Yu, L., Zhu, Y., Geng, L., Xu, Y., & Zhao, M. (2024). Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: A network meta-analysis. British Journal of Nutrition, 131(9), 1513-1527.
Zhang, D., Liu, D., Jing, J., Jia, B., Tian, Y., Le, Y., Yu, Y., & Hu, Q.-N. (2024). Unveiling the chemical complexity of food-risk components: A comprehensive data resource guide in 2024. Trends in Food Science & Technology, 104513.
Zyoud, S. H., & Zyoud, A. H. (2023). Water, sanitation, and hygiene global research: evolution, trends, and knowledge structure. Environmental Science and Pollution Research, 30(56), 119532-119548.
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