EDIBLE VACCINE IS A NATURAL WAY OF VACCINATION: A REVIEW ARTICLE

Authors

  • Faizan ul Haque Nagrami College of Biotechnology, DUVASU, Mathura, India (281001)
  • Shweta Sharma College of Biotechnology, DUVASU, Mathura, India (281001)
  • Uma Sharma College of Biotechnology, DUVASU, Mathura, India (281001)
  • Akshita Tiwari College of Biotechnology, DUVASU, Mathura, India (281001)
  • Parul Singh College of Biotechnology, DUVASU, Mathura, India (281001)

DOI:

https://doi.org/10.59436/jsiane.com/archives3/12/72

Keywords:

Plant Bioreactors; Plant-Based Edible Vaccines; Plant Biotechnology, Comestible vaccine Transgenic Plant; Genetic Engineering

Abstract

Many people have high hopes for edible vaccinations because they are inexpensive, easy to administer, safe, convenient to store, practically impossible to mess up, and socially and culturally sustainable even in developing countries. Instead of painful injections, a vaccine that can be eaten is used. Unlike traditional vaccines, edible vaccines are less expensive, require no needles, don't need to be preserved, are non-offensive, may be stored close to where they'll be used, and provide both mucosal and total protection. Edible vaccinations are being produced for a wide range of infectious diseases, including cholera, measles, foot-and-mouth disease (FMD), and hepatitis B. Autoimmune diseases like type I diabetes are easier to beat with the aid of edible vaccinations. Several diseases in both humans and animals are currently being researched with the goal of creating edible vaccinations. Transgenic crops are gaining popularity in both developed and poor nations. Edible vaccines face an uncertain future in the face of public opposition to transgenic foods. The most significant barriers to a developing vaccination technology have been overcome. There are a number of technical roadblocks, as well as regulatory and non-scientific difficulties, but they all appear to be manageable. In this article, we'll try to discuss where things stand and where they're going with this innovative form of disease prevention. The two main benefits of edible vaccines are generational immunization and the treatment of malnutrition. If the major difficulties can be overcome, it could lead to a windfall of more safe and more effective vaccine.

References

Kurup VM, Thomas J (2020) Edible vaccines: promises and challenges. Mol Biotechnol 62(2): 79-90.

Özdemir M, Afacan M (2001) Chapter 4. Administration of Vaccines and Adjuvants Used in Vaccines, In Preventive Medicine, pp: 71.

Kaya H, Özdemir M (2021) Chapter 2. Vaccine Technologies and Domestic Vaccines, In Preventive Medicine, pp: 18

Razna AI (2022) Progress of edible vaccine development.

Akdeniz M, Kavukcu E (2016) Aşılama ve aşıların tarihçesi. Klinik Tıp Aile Hekimliği 8(2): 11-28.

Hefferon KL (2010) The mucosal immune response to plant-derived vaccines. Pharm Res 27(10): 2040-2042.

Okay A, Aydın S, Büyük İ, Aras ES (2021) Plant-derived vaccines. Biological Diversity and Conservation 14(1): 167-174.

Hemmer W (2005) Foods Derived from Genetically Modified Organisms and Detection Methods. BATS.

Topal S (2004) Genetik Değiştirme İşlemleri ve Biyogüvenlik. Buğday 26.

Mahmood N, Nasir SB, Hefferon K (2021) Plant-Based Drugs and Vaccines for COVID-19. Vaccines 9(1): 15.

Güler B, Bayraktar M, Gürel A (2021) Covid-19 İle Mücadelede Bitkilerin Olası Rolü. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi 10(2): 866- 880.

Rigano MM, Walmsley AM (2005) Expression systems and developments in plant-made vaccines. Immunol Cell Biol 83(3): 271-277.

Gunasekaran B, Gothandam KM. (2020). A review on edible vaccines and their prospects. Braz J Med Biol Res. 24;53(2): e8749. doi: 10.1590/1414-431X20198749. PMID: 31994600; PMCID: PMC6984374.

Webster DE, Thomas MC, Strugnell RA, Dry IB, Wesselingh SL. (2002) Appetising solutions: an edible vaccine for measles. Med J Aust.; 176:434–437.

Giddings G, Allison G, Brooks D, Carter A. (2000). Transgenic plants as factories for biopharmaceuticals. Nat Biotechnol ; 18:1151–1155. doi: 10.1038/81132.

Johansen FE, Pekna M, Norderhaug IN, Haneberg B, Hietala MA, Krajci P, et al. (1999). Absence of epithelial immunoglobulin a transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J Exp Med; 190:915–922. doi: 10.1084/jem.190.7.915.

Walmsley AM, Arntzen CJ. Plants for delivery of edible vaccines. (2000) Curr Opin Biotechnol; 11:126–129. doi: 10.1016/S0958-1669(00)00070-7.

Munshi A, Sharma V (2018) Omics and Edible Vaccines. Omics Technologies and BioEngineering 2: 129-141.

Concha C, Cañas R, Macuer J, Torres MJ, Herrada AA, et al. (2017) Disease prevention: an opportunity to expand edible plant-based vaccines? Vaccines (Basel) 5(2): 14.

Shah CP, Trivedi MN, Vachhani UD, Joshi VJ (2011) Edible Vaccine: a Better Way for Immunization. Clinical Trials 3(1): 1-4.

Han M, Su T, Zu YG, An ZG (2006) Research advances on transgenic plant vaccines. Yi Chuan Xue Bao 33(4): 285- 293.

Jelaska S, Mihaljević S, Bauer N (2014) Production of Biopharmaceuticals, Antibodies and Edible Vaccines in Transgenic Plants. Current Studies of Biotechnology 4(5): 121128.

Morton J (1987) Banana. In: Fruits of Warm Climates. JF Morton Miami USA, pp: 29- 46.

Saxena J, Rawat S (2013) Edible Vaccines. Advances in Biotechnology pp: 207-226.

Gu Q, Han N, Liu J, Zhu M (2006) Expression of Helicobacter pylori urease subunit B gene in transgenic rice. Biotechnol Lett 28(20): 1661-1666.

Nojima J, Ishii-Katsuno R, Futai E, Sasagawa N, Watanabe Y, et al. (2011) Production of anti-amyloid β antibodies in mice fed rice expressing amyloid β. Biosci Biotechnol Biochem 75(2): 396-400.

Wu J, Yu L, Li L, Hu J, Zhou J, et al. (2007) Oral immunization with transgenic rice seeds expressing VP2 protein of infectious bursal disease virus induces protective immune responses in chickens. Plant Biotechnol J 5(5): 570-578.

Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, et al. (2013) Induction of toxinspecific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant‐associated sugar modification. Plant Biotechnol J 11(7): 799-808.

Gumul D, Ziobro R, Noga M, Sabat R (2011) Characterisation of five potato cultivars according to their nutritional and pro-health components. Acta Sci Pol Technol Aliment 10(1): 77-81.

Dinc S, Kara M, Arslanoglu SF (2014) Patates Ve Sağlık. Türk Tohumcular Birliği Dergisi pp: 43-44.

Evers D, Deusser H (2012) Potato Antioxidant Compounds: Impact of Cultivation Methods and Relevance for Diet and Health. In: Bouayed J, et al. (Eds.), Nutrition, Well-Being and Health. Intechopen.

Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, et al. (2008) Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 17(1): 171-182.

Budak N (2002) The importance of folic acid in woman and child health. Erciyes Medical Journal 24(4): 209-214.

Rybicki EP (2010) Plant-made vaccines for humans and animals. Plant Biotechnol J 8(5): 620-637.

Aryamvally A, Gunasekaran V, Narenthiran KR, Pasupathi R (2017) New strategies toward edible vaccines: an overview. J Diet Suppl 14(1): 101-116.

Roy S, Bhattacharyya P (2020) Possible role of traditional İsmail Karakaş and Fatma Aykut Tonk. Plants That Can be Used as Plant-Based Edible Vaccines; Current Situation and Recent Developments. Virol Immunol J 2022, 6(3): 000302.

İsmail Karakaş and Fatma Aykut Tonk. medicinal plant Neem (Azadirachta indica) for the management of COVID-19 infection. Int J Res Pharm Sci 1(11): 122-125.

Al-Hashemi ZSS, Hossain MA (2016) Biological activities of different neem leaf crude extracts used locally in Ayurvedic medicine. Pacific Science Review A: Natural Science and Engineering 18(2): 128-131.

Sujarwo W, Keim AP, Caneva G, Toniolo C, Nicoletti M, et al. (2016) Ethnobotanical uses of neem (Azadirachta indica A. Juss.; Meliaceae) leaves in Bali (Indonesia) and the Indian subcontinent in relation with historical background and phytochemical properties. J Ethnopharmacol 189: 186-193.

Parida MM, Upadhyay C, Pandya G, Jana AM (2002) Inhibitory potential of neem (Azadirachta indica Juss) leaves on dengue virus type-2 replication. J Ethnopharmacol 79(2): 273-278.

Thakurta P, Bhowmik P, Mukherjee S, Hajra TK, Patra A, et al. (2007) Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India. J Ethnopharmacol 111(3): 607-612.

Tregoning JS, Nixon P, Kuroda H, Svab Z, Clare S, et al. (2003) Expression of tetanus toxin fragment C in tobacco chloroplasts. Nucleic Acids Res 31(4): 1174-1179.

Balfour H (2020) Using plants as bioreactors to produce proteins for therapeutics. European Pharmaceutical Review.

Kohl T, Hitzeroth II, Stewart D, Varsani A, Govan VA, et al. (2006) Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proofofconcept study. Clin Vaccine Immunol 13(8): 845-853.

Varsani A, Williamson AL, Rose RC, Jaffer M, Rybicki EP, et al. (2003) Expression of Human papillomavirus type 16 major capsid protein in transgenic Nicotiana tabacum cv. Xanthi. Arch Virol 148(9): 1771-1786.

Santi L, Batchelor L, Huang Z, Hjelm B, Kilbourne J, et al. (2008) An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine 26(15): 1846-1854.

Kumar S, Tiku AB (2016) Immunomodulatory potential of acemannan (polysaccharide from Aloe vera) against radiation induced mortality in Swiss albino mice. Food and Agricultural Immunology 27(1): 72-86.

Zandi K, Zadeh MA, Sartavi K, Rastian Z (2007) Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. African Journal of Biotechnology 6(15): 1770-1773.

Mpiana PT, Ngbolua KTN, Tshibangu DST, Kilembe JT, Gbolo BZ, et al. (2020) Aloe vera (L.) Burm. F. as a Potential Anti-COVID-19 Plant: A Mini-review of Its Antiviral Activity. European Journal of Medicinal Plants 31(8): 86-93.

Kahlon JB, Kemp MC, Carpenter RH, McAnalley BH, McDaniel HR, et al. (1991). Inhibition of AIDS virus replication by acemannan in vitro. Mol Biother 3(3): 127-135.

Barnard DL, Huffman JH, Morris JL, Wood SG, Hughes BG, et al. (1992) Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. Antiviral Res 17(1): 63-77.

Semple SJ, Pyke SM, Reynolds GD, Flower RL (2001) In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral Res 49(3): 169-178.

Rosales-Mendoza S, Soria-Guerra RE, López-Revilla R, Moreno-Fierros L, Alpuche-Solís AG, et al. (2008) Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Rep 27(1): 79-84.

Bhatia S and Dahiya R. (2015) Edible Vaccines. Modern Applications of Plant Biotechnology in Pharmaceutical Sciences. Pages 333-343, ISBN 9780128022214.

Prakash C (1996) Edible vaccines and antibody producing plants. Biotechnol Dev Monit 27: 10-13.

Waghulkar V (2010) Fruit derived edible vaccines: Natural way for the vaccination. Int J PharmTech Res 2: 2124-2127.

Dus Santos MJ, Wigdorovitz A, Trono K, Ríos RD, Franzone PM, et al. (2002) A novel methodology to develop a foot and mouth disease virus (FMDV) peptide-based vaccine in transgenic plants. Vaccine 20: 1141-1147.

Domansky N, Ehsani P, Salmanian AH, Medvedeva T (1995) Organ-specific expression of hepatitis B surface antigen in potato. Biotechnology letters 17: 863-866.

Khan A, Khan A, Khan I, Shehzad MA, Ali W, et al. (2019) A review on natural way of vaccination: Plant derived edible vaccines. J Vaccines Immunol 5(1): 018-021. DOI: 10.17352/jvi.000025

Singh YP, Dhangrah VK, Chaubey AN, Singh V (2022) Chapter-36. Genetic Engineering: It’s Role in Agriculture.

Mandal-Ghosh I, Chattopadhyay U, Baral R (2007) Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen. Cancer Immunity Archive 7(1): 8.

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Published

2023-03-26

How to Cite

EDIBLE VACCINE IS A NATURAL WAY OF VACCINATION: A REVIEW ARTICLE . (2023). Journal of Science Innovations and Nature of Earth, 3(1), 37-45. https://doi.org/10.59436/jsiane.com/archives3/12/72

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