ROLE OF OXIDATIVE STRESS IN POTASSIUM BROMATE-INDUCED NEPHROTOXICITY AND REPRODUCTIVE TOXICITY
DOI:
https://doi.org/10.59436/551hbx75Keywords:
Potassium bromate, nephrotoxicity, reproductive toxicity, oxidative stress, antioxidant enzymes, reactive oxygen species, rodent modelAbstract
This study investigates the nephrotoxic and reproductive toxic effects of potassium bromate (KBrO3), a compound with widespread industrial applications but concerning toxicological profiles. Employing male and female rodent models, the research aims to elucidate the role of oxidative stress in KBrO3-induced toxicity. Animals were divided into control and treatment groups, receiving varying doses of KBrO3. Key parameters assessed included serum creatinine and blood urea nitrogen for renal function; reactive oxygen species (ROS) and malondialdehyde (MDA) levels for oxidative stress; and activities of antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT). Histological analyses of kidney, testes, and ovaries, alongside gene expression studies of oxidative stress markers, provided insights into the cellular impact of KBrO3 exposure. The findings indicate a significant dose-dependent increase in oxidative stress markers, alongside notable renal and reproductive tissue damage, underscoring the critical role of oxidative stress in KBrO3 toxicity. These results highlight the urgent need for regulatory measures to mitigate exposure risks and protect public health.
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