From Nature to Treatment: Unraveling the Healing Potential of Phytotherapy in Inflammatory Bowel Disease (IBD) - A Comprehensive Review

Authors

  • Dr. Kanta Rani Department of Botany, GGDSD College, Palwal 121102, Haryana, India
  • Dr. Manisha Agrawal Department of Botany, GGDSD College, Palwal 121102, Haryana, India
  • Dr. Vandana Kalra Department of Zoology, GGDSD College, Palwal 121102, Haryana, India
  • Dr. Neha Bhatnagar Department of Zoology, GGDSD College, Palwal 121102, Haryana, India

DOI:

https://doi.org/10.59436/jsiane.326.2583-2093

Keywords:

Inflammatory Bowel Disease IBD, Ulcerative colitis, Crohn’s disease, Phytotherapy

Abstract

Inflammatory Bowel Disease is an idiopathic, refractory disease that causes chronic inflammation of the entire alimentary canal. It is associated with two major disorders, namely, ulcerative colitis (UC) and Crohn’s disease (CD). Ulcerative Colitis,is responsible for long-term inflammation and soreness in the innermost lining of the colon and rectum. In Crohn’s disease, the entire lining of the digestive tract becomes inflamed, especially the terminal ileum of the small intestine. For the treatment of IBD, medical prescriptions include antibiotics, immunosuppressants, topical and systemic corticosteroids, 5-aminosalicylates, etc. However, all these medications have major side effects on human health. Besides these chemical treatments, phytotherapy can also be used as an alternative treatment. Some medicinal plants used  to treat IBD include Curcuma longa, Vacciniummyrtillus, Pistacialentiscus, Aloe vera, Boswelliaserrata, Triticumaestivum (wheatgrass), Hordeumvulgare (germinated Barley foodstuff) , Commiphorawightii, Matricariachamomilla, Glycyrrhizaglabra, Althaea officinalis, Plantagopsyllium, etc. Nowadays, phytotherapy is gaining more attention for the treatment of various diseases owing to its being safer and cheaper than conventional drugs. This paper highlights the competence of phytotherapy in the treatment of IBD by shedding light on its efficacy and adequacy.

References

Barrett, K., Saxena, S. and Pollok, R..Using corticosteroids appropriately ininflammatory bowel disease: a guide for primary care. British Journal of GeneralPractice, 2018; 68(675):497-498.

Boutemine, I.M., Amri, M., Dorgham, K., Amir, Z.C., Benazzouz, S., Ameur, F., Layaida, K.,Yssel, H. and Touil-Boukoffa, C.. Beneficial role of Pistacialentiscusaqueousextract in experimental colitis: anti-inflammatory and potential therapeuticeffects. Inflammopharmacology. 2021; 29:1225-1239.

Bruscoli, S., Febo, M., Riccardi, C. and Migliorati, G. Glucocorticoid therapyin inflammatory bowel disease: mechanisms and clinical practice. Frontiers inimmunology. 2021; 12 :691480.

Catanzaro, D., Rancan, S., Orso, G., Dall’Acqua, S., Brun, P., Giron, M.C., Carrara,M., Castagliuolo, I., Ragazzi, E., Caparrotta, L. and Montopoli, M. Boswelliaserrata preserves intestinal epithelial barrier from oxidative and inflammatorydamage. PloS one, 2015; 10(5) :0125375.

Colombel, J.F., Shin, A. and Gibson, P.R. AGA clinical practice update on functionalgastrointestinal symptoms in patients with inflammatory bowel disease: expertreview. Clinical Gastroenterology and Hepatology. 2019; 17(3):380-390.

Coward, S., Kuenzig, M.E., Hazlewood, G., Clement, F., McBrien, K., Holmes, R.,Panaccione, R., Ghosh, S., Seow, C.H., Rezaie, A. and Kaplan, G.G. Comparative effectiveness of mesalamine, sulfasalazine, corticosteroids, andbudesonide for the induction of remission in Crohn's disease: a Bayesiannetwork meta-analysis. Inflammatory bowel diseases. 2017 ; 23(3) :461-472.

Cunha Neto, F., Marton, L.T., de Marqui, S.V., Lima, T.A. and Barbalho, S.M..Curcuminoids from Curcuma Longa: New adjuvants for the treatment ofcrohn's disease and ulcerative colitis?. Critical reviews in food science andnutrition. 2019;59(13) :2136-2143.

Dharni, K., Singh, A., Sharma, S., Midha, V., Kaur, K., Mahajan, R., Dulai, P.S. and Sood,A.Trends of inflammatory bowel disease from the Global Burden ofDisease Study (1990-2019). Indian Journal of Gastroenterology. 2024;43(1):188-198.

Dutta, A.K. Indian Journal of Gastroenterology—January–February 2024 issuehighlights. Indian Journal of Gastroenterology. 2024:1-6.

El Joumaa, M.M. and Borjac, J.M. Matricariachamomilla: A valuable insight intorecent advances in medicinal uses and pharmacological activities. PhytochemistryReviews. 2022;21(6):1913-1940.

El-Rhman, A.A.The Impact of Flaxseed (Linumusitatissimum L.) and PsylliumSeed (PlantagoOvata P.)Oils on Hemogram, Oxidative Stress and Inflammation inUlcerative Colitis Rat Model. Egyptian Academic Journal of Biological Sciences, CPhysiology & Molecular Biology. 2022; 14(2).

Ford, A.C., Achkar, J.P., Khan, K.J., Kane, S.V., Talley, N.J., Marshall, J.K. and Moayyedi,P. Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review andmeta-analysis. Official journal of the American College of Gastroenterology|ACG. 2011; 106(4) :601-616.

Grace, A.G., Usman, M.A., Ochayi, M.O., Adams, M.D., Umar, H.D.A., Obalum, C.D.,Akunna, G.G., Meraiyebu, A.B. and Onwuchekwa, C. Elucidating the anti-oxidant and anti-inflammatory potentials of Triticumaestivum against ulcerativecolitis: An in vivo and in silico study. Gastroenterology & hepatology. 2022; 12(12):720-727.

Kianitalaei, A., Feyzabadi, Z., Hamedi, S. and Qaraaty, M. Althaea Officinalis inTraditional Medicine and modern phytotherapy. J. Adv. Pharm. Educ. Res. 2019; 9:155.

Kunnumakkara, A.B., Banik, K., Bordoloi, D., Harsha, C., Sailo, B.L., Padmavathi, G., Roy,N.K.,Gupta, S.C. and Aggarwal, B.B. Googling the Guggul (Commiphora andBoswellia) for prevention of chronic diseases. Frontiers in pharmacology. 2018; 9:686.

Langmead, L., Makins, R.J. and Rampton, D.S. Anti‐inflammatory effects of aloevera gel in human colorectal mucosa in vitro. Alimentary pharmacology &therapeutics. 2004; 19(5):521-527.

Leite, C.D.S., Bonafé, G.A., Carvalho Santos, J., Martinez, C.A.R., Ortega, M.M. andRibeiro, M.L. The anti-inflammatory properties of licorice (Glycyrrhizaglabra)-derived compounds in intestinal disorders. International journal ofmolecular sciences. 2022; 23(8): 4121.

Lewis, J.D., Gelfand, J.M., Troxel, A.B., Forde, K.A., Newcomb, C., Kim, H., Margolis, D.J.and Strom,B.L. Immunosuppressant medications and mortality ininflammatory bowel disease. Official journal of the American College ofGastroenterology| ACG. 2008; 103(6) :1428-1435.

Lim, T.K. and Lim, T.K. Hordeumvulgare. Edible Medicinal And Non-MedicinalPlants: Volume 5, Fruits. 2013 : 267-300.

Minordi, L.M., Bevere, A., Papa, A., Larosa, L. and Manfredi, R. CT and MRIevaluations in Crohn's complications: a guide for the radiologist. AcademicRadiology. 2022; 29(8) :1206-1227.

Parente, F., Greco, S., Molteni, M., Anderloni, A., Sampietro, G.M., Danelli, P.G., Bianco,R., Gallus, S. and Porro, G.B. Oral contrast enhanced bowelultrasonography in the assessment of small intestine Crohn’s disease. Aprospective comparison with conventional ultrasound, x ray studies, andileocolonoscopy. Gut. 2004;53(11):1652-1657.

Parente, F., Molteni, M., Marino, B., Colli, A., Ardizzone, S., Greco, S., Sampietro, G.,Foschi, D. and Gallus, S. Are colonoscopy and bowel ultrasound useful forassessing response to short-term therapy and predicting disease outcome ofmoderate-to-severe forms of ulcerative colitis?: a prospective study. Officialjournal of the American College of Gastroenterology| ACG. 2010;105(5):1150-1157.

Perencevich, M. and Burakoff, R. Use of antibiotics in the treatment ofinflammatory bowel disease. Inflammatory bowel diseases. 2006; 12(7) :651-664.

Schoepfer, A.M., Trummler, M., Seeholzer, P., Seibold-Schmid, B. and Seibold, F. Discriminating IBD from IBS: comparison of the test performance of fecal markers,blood leukocytes, CRP, and IBD antibodies. Inflammatory bowel diseases. 2008; 14(1):32-39.

Schreyer, A.G., Seitz, J., Feuerbach, S., Rogler, G. and Herfarth, H. Modernimaging using computer tomography and magnetic resonance imaging forinflammatory bowel disease (IBD) AU1. Inflammatory bowel diseases. 2004;10(1) :45-54.

Sharma, A. and Lee, H.J. Anti-inflammatory activity of bilberry (Vacciniummyrtillus L.). Current issues in molecular biology. 2022; 44(10) :4570-4583.

Zhang, L., Liu, F., Xue, J., Lee, S.A., Liu, L. and Riordan, S.M.,. Bacterial speciesassociated with human inflammatory bowel disease and their pathogenicmechanisms. Frontiers in Microbiology. 2022;13 :801892.

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Published

2025-03-01

How to Cite

From Nature to Treatment: Unraveling the Healing Potential of Phytotherapy in Inflammatory Bowel Disease (IBD) - A Comprehensive Review. (2025). Journal of Science Innovations and Nature of Earth, 5(1), 19-22. https://doi.org/10.59436/jsiane.326.2583-2093

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