PHYTOCHEMISTRY AND MEDICINAL USES OF CARICA PAPAYA (LINN.): A REVIEW
DOI:
https://doi.org/10.59436/jsiane.com/archives3/12/70Keywords:
Nutraceuticals, Carica papaya, Anticancer, Antimicrobial, Phytochemicals, Traditional medical system, Bio-pharmacological potencyAbstract
The plant world is the gold mine of contemporary medicine because of the abundance of bioactive compounds and secondary metabolites it contains. In fact, it is a therapeutic and preventative dietary supplement that helps the body resist disease and age more gracefully. The papaya (Carica papaya L.), featured above, is an associate of the Caricaceae family and is widely regarded for its useful nutritional and therapeutic benefits around the world. Papaya's nutritional and medicinal value comes from its many parts, including its leaves, roots, skin, fruit, and seeds. It thrives in warm, humid climates and is widely distributed throughout the tropics and subtropics. This review aims to synthesize, by the end of 2022, data on papaya's functional activity culled from electronic sources, including Dimensions, Scopus, Google Scholar, Web of Science and Science Direct. Papaya is a good dietary supplement because of the wealth of research detailing the plant's utilization of many medicinal chemicals. Numerous vitamins, minerals, and enzymes, including papain, glycylendopeptidase, chymopapain, and caricain, can be found in plant extracts, notably those made from the fruits and leaves. These chemicals have anticancer actions; reduce inflammation, hyperglycemia, infertility, hypertension problems, and more thanks to their intriguing nutraceutical qualities. Papaya seeds peel, and leave have medical promise, but additional study is needed to determine dosage, mechanism of action, and safety profile. Therefore, this review urges the implementation of public health awareness initiatives to encourage the consumption of papaya so that the general public can reap the fruit's full potential in preventing and treating disease.
References
Agada, R., Usman, W.A., Shehu, S. and Thagariki, D. (2020). In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes Heliyon, 6 (3).
Ahmad, I. and Beg, A. (2001). Antimicrobial and phytochemicals studies on 45 indian medicinal plants against multidrug resistant human pathogens Ethnopharm. 74(87): 113-23.
Alara, O.R., Abdurahman, N.H. and Alara, J.A. (2022). Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities, Advances in Traditional Medicine, 22: 17–47.
Ali, A., Devarajan, S., Waly, M., Essa, M.M. and Rahman, M. (2011). Nutritional and medicinal value of papaya (Carica papaya L.),” in Natural Products and Bioactive Compounds in Disease Prevention. Nova Science Publishers, pp. 34-42.
Anitha, B., Raghu, N., Gopenath, T.S., Karthikeyan, M., Gnanasekaran, A., Chandrashekrappa, G.K. and Basalingappa, K.M. (2018). Medicinal Uses of Carica papaya. J Nat Ayu Med., 2(6): 000144.
Aravind, G., Bhowmik, D., Duraivel, S. and Harish, G. (2013). Traditional and Medicinal Uses of Carica papaya. J Med Plants Stud, 1:7-15.
Archampong, T.N., Asmah, R.H., Richards, C.J., Martin, V.J., Bayliss, C.D., Botão, E., David, L., Beleza, S. and Carrilho, C. (2019). Gastro-duodenal disease in Africa: literature review and clinical data from accra, Ghana World J. Gastroenterol., 25(26): 3344-3358.
Aruoma, O.I., Somanah, J., Bourdon, E., Rondeau, P. and Bahorun, T. (2014). Diabetes as a risk factor to cancer: functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer. Mutat. Res., 768 (C).
Azarkan, A.M., Moussaoui, E., Wuytswinkel, D. van, Dehon, G., Looze, Y. (2003). Fractionation and purification Analyt Technol of the enzyme stored in the latex of Carica papaya. J Chromatogr B Biomed Appl, 790: 229-238.
Azevedo, L. and Campagnol, P. (2014). Papaya seed flour (Carica papaya) affects the technological and sensory quality of hamburgers, Int. Food Res. J., 21(6): 2141.
Bushra, I., Fozia Abdul, W., Ali, R., Ullah, H., Iqbal, H., Almas, M. and Ahmad, A. (2012). Antimicrobial activity of Malvaneglecta and Nasturtium microphyllum. Int J Res Ayurveda Pharm, 3: 808-810.
Chandra, G., Bhattacharjee, I., Chatterjee, S.K. and Ghosh, A. (2011). Antibacterial activities of some plant extracts used in Indian traditional folk medicine. Asian Pac J Trop Biomed, S165-S169.
Chávez-Quintal, P., González-Flores, T., Rodríguez-Buenfil, I., Gallegos-Tintoré, S. (2011). Antifungal activity in ethanolic extracts of Carica papaya L. cv. Maradol leaves and seeds. Indian J. Microbiol., 51(1): 54-60.
Cohen, M.L. (1992). Epidemiology of drug resistance: implications for a postantimicrobial era. Science, 257: 1050-1055.
Doan, M.T.N., Huynh, M.C., Pham, A.N.V., Chau, N.D.Q., Le, P.T.K. (2020). Extracting seed oil and phenolic compounds from papaya seeds by ultrasound-assisted extraction method and their properties, Chem. Eng. Trans. 78: 493–498.
Drenth, J., Jansonius, J.N., Koekoek, R., Wolthers, H.M. (1968). Structure of papain. Nature, 218: 929-932.
Ejeh, E., Dan, V.M., Dikwa, K.B. and Mshelia, A.S. (2022). Assessment of the effects of ripe Carica papaya seeds extracts on MCF-7 Breast cancer cell lines. ISOR J Biotech Biochem, 8(1): 12-1.
Ellof, J.N. (1998). Which extractant should be used for the screening and isolation of antimicrobial components from plants? J. Ethnopharmacol. 60: 1-6.
Emeruwa A.C. (1982). Antibacterial substance from Carica papaya fruit extract. J. Nat. Prod., 45(2): 123-127.
Ezike, A.C., Akah, P.A., Okoli, C.O., Ezeuchenne, N.A., Ezeugwu, S. (2009). Carica papaya (Paw-Paw) unripe fruit may be beneficial in ulcer. J. Med. Food, 12(6): 1268-1273.
Fatima, U. and Shahid, S. (2018). Pharmacological Activities of Carica papaya Linn. J Basic Appl Sci, 14: 210-216.
Garrett, A. (1995). The pollination biology of papaw (Carica papaya L.) in Central Queensland. PhD Thesis, Central Queensland University, Rockhampton, 125 pp.
He, X., Ma, Y., Yi, G., Wu, J., Zhou, L., Guo, H. (2017). Chemical composition and antifungal activity of Carica papaya linn. Seed essential oil against Candida spp. Lett. Appl. Microbiol., 64 (5) (2017), pp. 350-354.
Hillson R. Herbs and Diabetes, 36, John Wiley & Sons (2019), pp. 159-160.
Indran M., Mahmood A.A. , Kuppusamy U.R.(2008). Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Med. J., 57(4): 323-326.
Juárez-Rojop, I.E., Díaz-Zagoya, J.C., Ble-Castillo, J.L., Miranda-Osorio, P.H., Castell-Rodríguez, A.E., TovillaZárate, C.A., Rodríguez-Hernández, A., AguilarMariscal, H., Ramón-Frías, T., Bermúdez-Ocaña, D.Y. (2012). Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine; 12: 236.
Krishna, K.L., Paridhavi, M. and Patel, J.A. (2008). Review on nutritional, medicinal and pharmacological properties of papaya (Carica papaya Linn.). Natural Product Radiance 7(4): 364-373.
Laniado-Laborín, R. and Cabrales-Vargas, M.N. (2009). Amphotericin B: side effects and toxicity. Rev. Iberoam. Micol, 26(4): 223-227.
Mahendra, C.G. and Nikhil, D.A. (2016). Nutritional, medicinal and pharmacological properties of papaya (Carica papaya linn.): a review J. Innov. Pharm. Biol. Sci., 3(1): 162-169.
Mahendran, V.S., Sophiya, K., Sruthimalvika, S., Suganthi, B. and Sujitha, E. (2021). Carica papaya: Anticancer activity in MCF-7 Breast cancer cell lines. Int J Pharm Sci Res, 12(1): 176-182.
Maka, K.K., Tana, J.J., Marappana, P., Balijepallib, M.K., Choudhury, H., Ramamurthy, S., Pichika, M.R. (2018). Galangin's potential as a functional food ingredient. J. Funct. Foods, 46: 490-503.
Mantok, C. (2005). Multiple Usage of Green Papaya in Healing at Tao Garden. Tao Garden Health spa & Resort. Thailand.
Morace, G., Perdoni, F. and Borghi, E. (2014). Antifungal drug resistance in candida species. J. Glob. Antimicrob. Resist. 2(4): 254-259.
Mulyono, L.M. (2013). Antibacterial activity of papaya (Carica papaya L.) seed ethanol extract against Escherichia coli and Staphylococcus aureus, Jurnal Ilmiah MahasiswaUniversitas Surabaya, 2(2): 1-9.
Muss C, Mosgoeller W, Endler T. (2013). Papaya preparation (Caricol) in digestive disorders. Neuro Endocrinol Lett., 34: 38-46.
Nakamura, Y., Yoshimoto, M., Murata, Y., Shimoishi, Y., Asai, Y., Park, E.Y., Sato, K., Nakamura, Y. (2007). Papaya seed represents a rich source of biologically active isothiocyanate. J. Agric. Food Chem., 55(11): 4407-4413.
Nilugal, K., Fattepur, S., Veerapandian, V., Asmani, F., Bacayo, M., Abdulah, I., Yusuf, E. (2018). Evaluation of anti-ulcer effect of papaya juice in combination with cumin seed in ethanol induced peptic ulcers in experimental rats. Proceedings of the Bromo Conference, Symposium on Natural Products and Biodiversity, p. 94.
Oche, O., Rosemary, A., John, O., Chidi, E., Rebecca, S.M. and Vincent, U.A. (2017). Chemical constituents and nutrient composition of Carica papaya and Vernonia amygdalina leaf extracts. J. Complement. Altern. Med. Res., 1-8.
Odhong, C., Wahome, R.G., Vaarst, M.S., Nalubwama, W., Kiggundu, M., Halb, N., Githigia, S. (2014). In vitro anthelmintic effects of crude aqueous extracts of Tephrosia vogelii, tephrosia villosa and Carica papaya leaves and seeds, Afr. J. Biotechnol. 13(52): 4667–4672.
Okewumi, T.A. and Oyeyemi, A.W. (2012). Gastro-protective activity of aqueous Carica papaya seed extract on ethanol induced gastric ulcer in male rats. Afr. J. Biotechnol., 11(34): 8612-8615.
Olcum, M., Tastan, B., Ercan, I., Eltutan, I.B. and Genc, S. (2020). Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: a review, Phytomedicine. 75: 153-238.
Oloyede, H.O.B., Adaja, M.C., Ajiboye, T.O., Salawu, M.O. (2015). Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. J. Integr. Med., 13(2): 105-114.
Otsuki, N., Dang, N.H., Kumagai, E., Kondo, A., lwata, S. and Morimoto, C. (2010). Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol, 127: 760-767.
Pandey, P., Walpole, C., Shaw, P.N., Cabot, P.J., Hewavitharana, A.K. and Batra, J. (2018). Bio-Guided Fractionation of Papaya leaf juice for Delineating the Components Responsible for Selective Anti-proliferative Effects on Prostate Cancer cells. Front Pharmacol, 9: 1319.
Parray, Z.A., Parray, S.A., Khan, J.A., Zohaib, S., Nikhat, S. (2018). Anticancer activities of papaya (Carica papaya): A review. Cell Ortho Med Pharma Assoc, 8(4):201-205.
Patterson, A.D., Gonzalez, F.J. and Idle, J.R. (2010). Xenobiotic metabolism: a view through the metabolometer. Chem Res Toxicol., 23(5): 851- 860.
Peristiowati, Y., Puspitasari, Y., Indasah (2019). Effects of Papaya leaf Extract on Cellular Proliferation and Apoptosis in Cervical cancer Mice model. Phytothérapie, 17: 265-275.
Pham-Huy, L.A., He, H., Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. Int J Biomed Sci, 4(2):89-96.
Pretorius, C. and Walt, E. (2001). Purification and identification of active compound of Carpobrotusedulis L. J. Ethnopharn., 76: 87–91.
Priyadarshi, A. and Ram, B. (2018). A Review on pharmacognosy, phytochemistry and pharmacological activity of Carica papaya leaf. Int J Pharm Sci Res, 9(10): 4071-4078.
Rahmani, A.H. and Aldebasi, Y.H. (2016). Potential role of Carica papaya and their active constituents in the prevention and treatment of diseases. Int. J. Pharm. Pharm. Sci., 8(1): 11-15.
Rajkapoor, B., Jayakar, B. and Kavimani, S. (2002). Effect of Carica papaya on hepatotoxicity. Biol Pharm Bull., 25: 1645-1646.
Ranasinghe, P., Abeyeskera, W.P., Permakumara, G.A., Perera, Y.S., Gurugama, P., Guanatilake, S.B. (2012). In vitro erythrocyte membrane stabilization properties of Carica papaya L. leaf extract. Pharmacogn Res, 4(4): 196-202.
Roglic, G. (2016). WHO global report on diabetes: a summary. Int. J. Non Commun. Dis., 1: 3-8.
Saba, S. and Pattan, N. (2022). The Potential Health Benefits of Papaya Seeds. Int J Res Appl Sci Eng Tech, 10(1): 44-50.
Sadeque, M.Z., Begum, Z.A., Umar, B.U., Ferdous, A.H., Sultana, S., Uddin, M.K. (2012). Comparative efficancy of dried fruits of Carica papaya Linn. And Vitamin E on preventing hepatotoxicity in rats. Faridpur Med Coll J; 7: 29-32.
Santos, P.R.V., Oliveira, A.C.X., Tomassini, T.C.B. (1995). Controle microbiógico de produtos fitoterápicos. Rev. Farm. Bioquím. 31: 35-38.
Sasidharan, S., Sumathi, V., Jegathambigai, N.R. and Latha, L.Y. (2011). Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice. Nat Prod Res, 25(20): 1982-1987.
Shaw, J.E., Sicree, R.A. and Zimmet, P.Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87(1): 4-14.
Sheikh, N., Jahagirdar, V., Kothadia, S. and Nagoba, B. (2018). Antifungal drug resistance in candida species, pp. 254-258.
Shen, W., Han, J., Yan, P. et al. (2018). Soluble expression of biologically active methionine sulfoxide reductase B1 (PaMsrB1) from Carica papaya in Escherichia coli and isolation of its protein targets, Protein Expression and Purification, 146: 17–22.
Sianipar, M.P., Suwarso, E., Roshidah, R. (2018). Antioxidant and Anticancer Activities of Hexane fraction from Carica papaya L. Male Flower. Asian J Pharm Clin Res, 11(3): 81-83.
Singh, P., Kakkar, P., Singh, R.L. (2016). Protective Effect of Trigonella foenum-graecum and Foeniculum vulgare Mature Leaf Against tBHP induced Toxicity in Primary Rat Hepatocytes. J Exp Food Chem., 2: 111.
Singh, P., Singh, R.L. (2018). Quantification of Phytochemicals Imparting Antioxidant Activities in Commonly Used Vegetables. Int J Appl Sci Biotech, 6(2):107-112.
Singh, P., Singh, R.L. and Kakkar, P. (2016). Antioxidant, DNA Damage Protective and hepatoprotective Activities of Amorphophallus campanulatus. Int J Pharm Pharm Sci, 8(3): 330-338.
Singh, P.G., Madhu, S.B., Shailasreesekhar, G.T.S., Basalingappa, K.M. and Sushma, B.V. (2020). In vitro antioxidant, anti-inflammatory and anti-microbial activity of Carica papaya seeds, Global Journal of Medical Research, 20: 19–38.
Singh, S., Sharma, B., Kanwar, S.S., Kumar, A. (2016). Lead phytochemicals for anticancer drug development. Front. Plant Sci., 7: 1667.
Singh, S.P. and Sudhakar Rao, D.V. (2011). Papaya (Carica papaya L.). Postharvest Biology and Technology of Tropical and Subtropical Fruits, (pp.86-126e).
Singh, S.P., Kumar, S., Mathan, S.V., Tomar, M.S., Singh, R., Verma, P.K., Kumar, A., Kumar, S., Singh, R.P. and Acharya, A. (2020). Theraoeutic application of Carica papaya leaf extract in the management of human diseases. DARU J Pharm Sci, 28(2): 735-744.
Singh, S.P., Kumar, S., Tomar, M.S., Singh, R.K., Verma, P.K., Kumar, A., Kumar, S., Acharya, A. (2019). Aqueous extract of Carica papaya leaf elicits the production of TNF-α and modulates the expression of cell surface receptors in tumor-associated macrophages, Biosci. Biotechnol. Res. Commun. 12(4): 115–1122.
Singh, S.P., Mathan, S.V., Dheeraj, A., Tailor, D., Singh, R.P. and Acharya, A. (2019). Anticancer Effects and Associated Molecular Changes of Carica papaya against Prostate Cancer, In American Association for Cancer Research Annual Meeting, DOI, American Association for Cancer Research.
Soib, H.H., Ismail, H.F., Husin, F., Abu Bakar, M.H., Yaakob, H. and Sarmidi, M.R. (2020). Bioassay-guided different extraction techniques of Carica papaya (Linn.) Leaves on in vitro wound-healing activities, Molecules, 25(3): 517.
Sumana, S., Kumar, G.T. (2019). Breaking the Barrier of cancer through papaya extract and their formulation. Anticancer Agents Med Chem, 19(13): 1577-1587.
Tan, C.X., Tan, S.T., Tan, S.S. (2020). An overview of papaya seed oil extraction methods, Int. J. Food Sci. Technol, 55(4): 1506–1514.
Tona, L., Kambu, K., Ngimbi, N., Cimanga, K., Vlietinck, A.J. (1998). Antiamoebic and phytochemical screening of some congolese medicinal plants, J. Ethnophar macol, 61(1): 57–65.
Upko, G.E., Owalabi, M.A., Image, N.O.A., Oribayo, O.O., Ejiroghene, A.J. (2016). Effect of Carica papaya aqueous leaf extract on pharmacokinetic profile of ciprofloxacin in rabbits. Trop J Pharm Res, 16(1): 127-134.
Wadekar, A.B., Nimbalwar, M.G., Panchale, W.A., Gudalwar, B.R., Lanwar, J.V., Bakal, R.L. (2021). Morphology, Phytochemistry and Pharmacological aspects of Carica papaya : a review. GSC Biol Pharm Sci, 14(03): 234-248.
Wall, M.M. (2021). Ascorbic acid, vitamin A, and mineral composition of banana (Musa sp.) and papaya (Carica papaya) cultivars grown in Hawaii. J food Compos Anal, 19(5): 434-445.
Wang, X., Contreras, M.D.M., Xu, D., Xing, C., Wang, L. and Yang, D. (2020). Different distribution of free and bound phenolic compounds affects the oxidative stability of tea seed oil: a novel perspective on lipid antioxidation, LWT-Food Science and Technology, 129 109389.
WHO. (2004). Diabetes Action Now Booklet. Geneva, Switzerland: World Health Organization. 49(2).
Yogiraj, V., Goyal, P.K., Chauhan, C.S., Goyal, A., Vyas, B. (2015). Carica papaya Linn.:An overview. Int J Herb Med, 2(5): 01-08.
Zeng, Y., Ali, M.K., Du, J. et al. (2022). Resistant starch in rice: its biosynthesis and mechanism of action against diabetesrelated diseases, Food Reviews International, pp. 1–24.
Zhang, T. and Chen, W. (2017). The Candida albicans inhibitory activity of the extract from papaya (Carica papaya L.) seed relates to mitochondria dysfunction. Int. J. Mol. Sci., 18 (9).
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