The Antioxidant Activities of Secondary Metabolites in Medicinal Plants: A Comprehensive Review

Authors

  • Preetika Sharma Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India
  • Ambrish Kumar Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India
  • Hina Farheen Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India
  • Devesh Kumar Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India
  • Shivam Parmar Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India
  • Anil Kumar Principal, Maharaj Singh College (Affiliated to Maa Shakumbhari University) Saharanpur- 247120, Uttar Pradesh, India
  • Saroj Singh Chahar* Department of Botany, Raja Balwant Singh College (Affiliated to Dr. Bhimrao Ambedkar University) Agra- 282002, Uttar Pradesh, India

DOI:

https://doi.org/10.59436/jsiane.409.2583-2093

Keywords:

Secondary metabolites, Antioxidant, Free radicals, Medicinal plants, Flavonoids

Abstract

The antioxidant activity of medicinal plant secondary metabolites is examined in this review. Metabolic activities generate free radicals and unstable molecules; these substances, which include terpenoids, tannins, alkaloids, steroids, flavonoids, and phenolic acids, protect vital biomolecules including DNA, RNA, proteins, and lipids from harm. Oxidative stress, which includes free radicals, is associated with long-term health problems like diabetes, cancer, and heart disease. Eleutherine americana, Ocimum sanctum, Syzygium cumini , Dalchini, Saraca indica, Sita Ashok, and Syzygium cumini  are some medicinal plants that are high in these antioxidants. Other examples are Baobab, Tulsi, Adansonia digitata , Syzygium cumini , Syzygium cumini , and Red Bulb Plant. In order to use these secondary metabolites in functional foods, nutraceuticals, and medicines, it is crucial to understand their antioxidant processes, as highlighted in the review. When compared to synthetic compounds such as butylated hydroxy toluene (BHT) and butylated hydroxy anisole (BHA), natural antioxidants are a safer bet for health promotion and illness prevention.  

References

Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R. J., & Gupta, R. C. (2012). Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). Nutrition and cancer, 64(3), 428-438.

Arya, S. S., Pegu, K., & Sadawarte, P. D. (2019). Bioactive compounds and health benefits of jamun (Syzygium cumini ). In Bioactive Molecules in Food (pp. 2297-2315). Springer, Cham.

Bajpai, M. (2023). Phytochemistry and pharmacology of Syzygium cumini Roxb. ex DC: A review. Journal of Pharmacy and Pharmacology, 75(4), 482-501.

Benes, L., Ďuračková, Z., & Ferenčik, M. (1999). Chemistry, physiology and pathology of free radicals. Life sciences, 65(18-19), 1865-1874.

Bourgaud, F., Gravot, A., Milesi, S., & Gontier, E. (2001). Production of plant secondary metabolites: a historical perspective. Plant science, 161(5), 839-851.

Braca, A., Sinisgalli, C., De Leo, M., Muscatello, B., Cioni, P. L., Milella, L., ... & Sanogo, R. (2018). Phytochemical profile, antioxidant and antidiabetic activities of Adansonia digitata L. (Baobab) from Mali, as a source of health-promoting compounds. Molecules, 23(12), 3104.

Caragay, A. B. (1992). Cancer preventive foods and ingredients. Food Technol., 4, 65-68.

Chanda, S., & Dave, R. (2009). In-vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview. African Journal of Microbiology Research, 3(13), 981-996.

Croteau, R., Kutchan, T. M., & Lewis, N. G. (2000). Natural products (secondary metabolites). Biochemistry and molecular biology of plants, 24, 1250-1319.

da Silveira, J. S., Mertz, C., Morel, G., Lacour, S., Belleville, M. P., Durand, N., & Dornier, M. (2020). Alcoholic fermentation as a potential tool for coffee pulp detoxification and reuse: Analysis of phenolic composition and caffeine content by HPLC-DAD-MS/MS. Food Chemistry, 319, 126600.

Ernst, E. (1998). Harmless herbs? A review of the recent literature. The American journal of medicine, 104 (2), 170-178.

Farzaneh, V., & Carvalho, I. S. (2015). A review of the health benefit potentials of herbal plant infusions and their mechanism of actions. Industrial Crops and Products, 65, 247-258.

Foyer, C. H., & Noctor, G. (2011). Ascorbate and glutathione: the heart of the redox hub. Plant physiology, 155(1), 2-18.

Gill, S. S., & Tuteja, N. (2010). Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Plant physiology and biochemistry, 48(12), 909-930.

Gulcin, İ. (2020). Antioxidants and antioxidant methods: An updated overview. Archives of toxicology, 94(3), 651-715.

Gupta, A., Singh, P. P., Singh, P., Singh, K., Singh, A. V., Singh, S. K., & Kumar, A. (2019). Medicinal plants under climate change: impacts on pharmaceutical properties of plants. In Climate change and agricultural ecosystems (pp. 181-209). Woodhead Publishing.

Hakkim, F. L., Arivazhagan, G., & Boopathy, R. (2008). Antioxidant property of selected Ocimum species and their secondary metabolite content. Journal of Medicinal Plants Research, 2(9), 250-257.

Hernández, I., Alegre, L., Van Breusegem, F., & Munné-Bosch, S. (2009). How relevant are flavonoids as antioxidants in plants? Trends in plant science, 14(3), 125-132.

Ibrahim, A. Y., Mahmoud, M. G., & Asker, M. M. (2014). Anti-inflammatory and antioxidant activities of polysaccharide from Adansonia digitata : An In-vitro study. Int J Pharm Sci Rev Res, 25(2), 174-182.

Jain, C., Khatana, S., & Vijayvergia, R. (2019). Bioactivity of secondary metabolites of various plants: a review. Int. J. Pharm. Sci. Res, 10(2), 494-504.

Katiyar, S., Patidar, D., Gupta, S., Singh, R. K., & Singh, P. (2013). Some Indian traditional medicinal plants with antioxidant activity: a review. Int. J. Innovat. Res. Sci. Eng. Technol, 2, 7303-7314.

Kawamura, T., & Muraoka, I. (2018). Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint. Antioxidants, 7(9), 119.

Khalaf, N. A., Shakya, A. K., Al-Othman, A., El-Agbar, Z., & Farah, H. (2008). Antioxidant activity of some common plants. Turkish Journal of Biology, 32(1), 51-55.

Kılıç, C., Can, Z., Yılmaz, A., Yıldız, S., & Turna, H. (2017). Antioxidant properties of some herbal teas (green tea, senna, corn silk, rosemary) brewed at different temperatures. International Journal of Secondary Metabolite, 4 (3, Special Issue 1), 142-148.

Kuntorini EM, Astuti MD. 2010.Determination of the antioxidant activity of ethanol extract of Dayak onion (Eleutherine americana Merr.) bulbs. Sains dan Terapan Kimia 4 (1): 15-22. [Indonesian]

Kuntorini, E. M., Dewi, M., & Misrina, M. (2016). Anatomical structure and antioxidant activity of red bulb plant. Biodiversitas Journal of Biological Diversity, 17(1).

Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118.

Mandal, A. K., Poudel, M., Neupane, N. P., & Verma, A. (2022). Phytochemistry, pharmacology, and applications of Ocimum sanctum (Tulsi). In Edible Plants in Health and Diseases: Volume II: Phytochemical and Pharmacological Properties (pp. 135-174). Singapore: Springer Singapore.

Marčetić, M., & Arsenijević, J. (2023). The Antioxidant activity of plant secondary metabolites. Archives of Pharmacy, 73(Notebook 4), 264-277.

Mathew, S., & Abraham, T. E. (2006). In-vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies. Food and chemical toxicology, 44(2), 198-206.

Matkowski, A. (2008). Plant In-vitro culture for the production of antioxidants a review. Biotechnology advances, 26(6), 548-560.

Mbaebie, B. O., Edeoga, H. O., & Afolayan, A. J. (2012). Phytochemical analysis and antioxidants activities of aqueous stem bark extract of Schotia latifolia Jacq. Asian Pacific Journal of Tropical Biomedicine, 2(2), 118-124.

Merkl, R., HRádkoVá, I., FIlIp, V., & ŠMIdRkal, J. (2010). Antimicrobial and antioxidant properties of phenolic acids alkyl esters.

Mohiuddin, A. K. (2019). Chemistry of secondary metabolites. Ann Clin Toxicol. 2019; 2 (1), 1014.

Nalawade, S. M., Sagare, A. P., Lee, C. Y., Kao, C. L., & Tsay, H. S. (2003). Studies on tissue culture of Chinese medicinal plant resources in Taiwan and their sustainable utilization. Bot. Bull. Acad. Sin, 44(2), 79-98.

Ndiaye, E. M., Yousra, Y. E. I., Alioune, S., Ayessou, N. C., Harhar, H., Cisse, M., & Tabyaoui, M. (2021). Secondary metabolites and antioxidant activity of different parts of the baobab fruit (Adansonia digitata L.). Food and Nutrition Sciences, 12(7), 732-741.

Nwozo, O. S., Effiong, E. M., Aja, P. M., & Awuchi, C. G. (2023). Antioxidant, phytochemical, and therapeutic properties of medicinal plants: A review. International Journal of Food Properties, 26(1), 359-388.

Pagare, S., Bhatia, M., Tripathi, N., Pagare, S., & Bansal, Y. K. (2015). Secondary metabolites of plants and their role: Overview. Current trends in biotechnology and pharmacy, 9(3), 293-304.

Pammi, S. S., Suresh, B., & Giri, A. (2023). Antioxidant potential of medicinal plants. Journal of Crop Science and Biotechnology, 26(1), 13-26.

Patel, R., Patel, A., Desai, S., & Nagee, A. (2012). Study of secondary metabolites and antioxidant properties of leaves, stem and root among Hibiscus rosa-sinensis cultivars. Asian J. Exp. Biol. Sci, 3(4), 719-725.

Pham-Huy, L. A., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International journal of biomedical science: IJBS, 4(2), 89.

Rashed, K. (2014). Medicinal Plants with antioxidant Potential: A review. Hygeia Journal for.

Roaa, M. H. (2020). A review article: The importance of the major groups of plants secondary metabolism phenols, alkaloids, and terpenes. International Journal for Research in Applied Sciences and Biotechnology (IJRASB), 7(5), 354-358.

Roy, A., Khan, A., Ahmad, I., Alghamdi, S., Rajab, B. S., Babalghith, A. O., ... & Islam, M. R. (2022). Flavonoids a bioactive compound from medicinal plants and its therapeutic applications. BioMed research international, 2022(1), 5445291.

Senguttuvan, J., Paulsamy, S., & Karthika, K. (2014). Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for In-vitro antioxidant activities. Asian Pacific journal of tropical biomedicine, 4, S359-S367.

Singh, D., & Sharma, R. (2022). Advances in secondary metabolite research: Biosynthesis, regulation, and applications. Phytochemistry Reviews, 21(3), 789–812.

Sivapriya, T., & John, S. (2020). Qualitative, quantitative, and antioxidant analysis of phytochemicals present in Syzygium cumini species. Indian Journal of Health Sciences and Biomedical Research kleu, 13(2), 105-111.

Tiwari, R., & Rana, C. S. (2015). Plant secondary metabolites: a review. International Journal of Engineering Research and General Science, 3(5), 661-670.

Velioglu, Y., Mazza, G., Gao, L., & Oomah, B. D. (1998). Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. Journal of agricultural and food chemistry, 46(10), 4113-4117.

Velu, G., Palanichamy, V., & Rajan, A. P. (2018). Phytochemical and pharmacological importance of plant secondary metabolites in modern medicine. In Bioorganic phase in natural food: an overview (pp. 135-156). Cham: Springer international publishing.

Williams, R. J., Spencer, J. P., & Rice-Evans, C. (2004). Flavonoids: antioxidants or signalling molecules?. Free radical biology and medicine, 36(7), 838-849.

Wink, M. (2015). Modes of action of herbal medicines and plant secondary metabolites. Medicines, 2(3), 251-286.

Yadav, R., et al. (2021). Plant secondary metabolites in combating oxidative stress and diseases. Antioxidants, 10(9), 1455.

Yang, L., Wen, K. S., Ruan, X., Zhao, Y. X., Wei, F., & Wang, Q. (2018). Response of plant secondary metabolites to environmental factors. Molecules, 23(4), 762.

Published

2025-09-03

How to Cite

The Antioxidant Activities of Secondary Metabolites in Medicinal Plants: A Comprehensive Review. (2025). Journal of Science Innovations and Nature of Earth, 5(3), 04-07. https://doi.org/10.59436/jsiane.409.2583-2093

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